Abstract 121: Whole-Brain Intrinsic Connectivity in Nonsyndromic Craniosynostosis
نویسندگان
چکیده
PURPOSE: Nonsyndromic craniosynostosis (NSC) has been associated with a greater risk of neurocognitive aberrations such as learning disorders, memory and attention deficits, and visuospatial abilities. Previously, our group has performed resting-state functional MRI (fMRI) studies in patients with sagittal NSC (SSO), and has found altered functional connectivity that may underlie some of the neurocognitive deficits in these patients. This study seeks to determine if different forms of NSC, including metopic synostosis (MSO) and unilateral coronal synostosis (UCS), result in different aberrations of functional brain connectivity.
منابع مشابه
Abstract: Location and Time of Maximal Head Shape Change in Strip Craniectomy with Barrel Staves and Helmet Therapy by 2D and 3D Imaging for Treatment of Sagital Craniosynostosis.
PURPOSE: Neurocognitive studies in school-age children with craniosynostosis reveal lower scores compared to controls. Optimal age at surgery in craniosynostosis continues to be debated. In addition, individuals with craniosynostosis may undergo reoperation to improve residual skull irregularities. It is unknown whether reoperation affects neurocognitive outcome. This study examined impact of a...
متن کاملBrain morphology in nonsyndromic unicoronal craniosynostosis.
Studies of isolated craniosynostosis have shown biomechanical and biochemical influences on the craniofacial phenotype, resulting from both genetic and epigenetic factors. Much less attention has been directed toward the morphology of the brain, despite the interactive nature of the developing skull and developing brain. The aim of this study is to define the morphology of the brain in nonsyndr...
متن کاملNonsyndromic craniosynostosis.
Nonsyndromic craniosynostosis is more commonly encountered than syndromic cases in pediatric craniofacial surgery. Affected children display characteristic phenotypes according to the suture or sutures involved. Restricted normal growth of the skull can lead to increased intracranial pressure and changes in brain morphology, which in turn may contribute to neurocognitive deficiency. Management ...
متن کاملTreatment of Nonsyndromic Craniosynostosis Using Multi-Split Osteotomy and Rigid Fixation with Absorbable Plates
BACKGROUND Nonsyndromic craniosynostosis is a relatively common craniofacial anomaly and various techniques were introduced to achieve its operative goals. Authors found that by using smaller bone fragments than that used in conventional cranioplasty, sufficiently rigid bone union and effective regeneration capacity could be achieved with better postoperative outcome, only if their stable fixat...
متن کاملAbstract: Long-Term Outcomes at Skeletal Maturity Following Cranial Vault Remodeling and Fronto-Orbital Advancement for Metopic Craniosynostosis
RESULTS: SSO demonstrated decreased wholebrain intrinsic connectivity compared to controls in left BA-39 and bilateral BA-7’s (p=0.071), which are the superior parietal lobules and the angular gyrus. UCS had significantly decreased intrinsic connectivity throughout the prefrontal cortex (PFC, p=0.031). On seed-based analysis, UCS had significantly increased connectivity between left BA-40 and b...
متن کامل